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Research Group URL
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Alexander Pines
Professor of Chemistry
Glenn T. Seaborg Professor
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Email: pines@berkeley.edu
Office: D64A
Hildebrand Hall
Lab: D62
Hildebrand Hall |
Phone: (510) 642-1220
Fax: (510) 486-5744
Lab Phone: (510) 642-2094 |
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Research Interests:
NMR and MRI; Quantum Coherence; Solid State; Materials; Physical, Biophysical and Analytical Chemistry
Pines is a pioneer in the development of nuclear magnetic resonance (NMR) spectroscopy, particularly for solids. His program addresses the establishment of new concepts and techniques in NMR and its nephew, magnetic resonance imaging (MRI), in order to enhance their capability and extend their applicability for the investigation of molecular structure and organization in systems from materials to organisms. The study and diagnostic use of quantum spins interacting with each other and with other degrees of freedom require an understanding of quantum coherence and decoherence and the development of new theoretical and experimental methods, one outcome of which is the establishment of new methodologies and the accompanying design and fabrication of novel, next-generation NMR and MRI instrumentation. His innovations include contributions to multiple-pulse coherent averaging, time-reversal of dipolar couplings, cross-polarization and high resolution carbon-13 NMR, multiple-quantum coherence, multidimensional spectroscopy, zero-field NMR, and ideas and methods for novel sample spinning and correlation. Applications of his widely used techniques range from catalysts and polymers to liquid crystals and biomolecules. Recently, Pines and his group, together with collaborators in Chemistry, Chemical Engineering, Physics, Bioengineering and Chemical Biology, have introduced novel approaches to high-resolution ex-situ mobile scanning methods and devices for spectroscopy and imaging, novel magnets and probes with rotating samples and magnetic fields, enhanced NMR and MRI using laser-polarized noble gases, the development of functionalized biosensors for molecular targeted NMR and MRI (aimed, for example, toward porous materials, single cells, and tumors) in vitro and in vivo , and the enhancement of spectral and image sensitivity using superconducting (SQUID) and laser magnetometer detectors together with amplified "remote" detection; applications range from chemistry and physics to materials science and biomedicine.
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Alexander Pines is the Glenn T. Seaborg Professor of Chemistry at the University of California , Berkeley , Senior Scientist in the Materials Sciences Division of the Lawrence Berkeley National Laboratory, and Faculty Affiliate of QB3, the California Institute for Quantitative Biomedical Research; he is also a Governor of the Weizmann Institute of Science in Israel . He obtained his Ph.D. in Chemical Physics at MIT and joined the faculty at Berkeley in 1972. Pines and Richard R. Ernst were awarded the Wolf Prize for chemistry in 1991. Among his numerous other honors, Pines has received the Langmuir Award of the American Chemical Society and the Faraday Medal of the Royal Society of Chemistry. He is a member of the U.S. National Academy of Sciences, and a Foreign Member of the Royal Society (London); he is Doctor Honoris Causa at the University of Paris and the University of Rome, and past President of the International Society of Magnetic Resonance. Among his many lectureships, he has been Loeb Lecturer at Harvard University, Lord Lecturer at MIT, Roberts Lecturer at Caltech, Tetelman Fellow at Yale University, Harkins Lecturer at the University of Chicago, Max Born Lecturer at the Hebrew University of Jerusalem, Lord Todd Professor at Cambridge University, Hinshelwood Professor at Oxford University, and Professeur Joliot-Curie at the Ecole Supréieure de Physique et Chimie in Paris. A renowned educator, Pines has been recognized by the University of California's Distinguished Teaching Award, and has been mentor to generations of graduate students and postdoctoral fellows, the self-dubbed "Pinenuts," many of whom who hold leading positions worldwide.
Glenn T. Seaborg Professor, born 1945; B.Sc. Hebrew University of Jerusalem (1967); Ph.D. Massachusetts Institute of Technology (1972); ACS Nobel Signature Award in Graduate Education (1982); ACS Baekeland Medal for Pure Chemistry (1985); UC Distinguished Teaching Award (1986); Professeur Joliot-Curie, Ecole Superiere de Physique et Chemie, Paris (1987); Ernest O. Lawrence Award (1988); Bourke Medal of the Royal Society of Chemistry (1988); Member, National Academy of Sciences (1988); Pittsburgh Spectroscopy Award (1989); Hinshelwood Professor, Oxford University (1990); Wolf Prize in Chemistry (1991); ACS Harrison Howe Award (1991); Centenary Lectureship and Medal, Royal Society of Chemistry (1994); Robert Foster Cherry Great Teacher Award, Baylor University (1995); President's Chair, University of California (1993-1997); Ampere Advanced Institute in Honor of A. Pines' 50th Birthday, Varenna, Italy; DOE Award for Outstanding Scientific Achievement (1997); ACS Centennial Speaker, Journal of Physical Chemistry (1997); ACS Irving Langmuir Award in Chemical Physics (1998); F. A. Cotton Medal for Excellence in Chemical Research (1998); Lord Todd Professor, Cambridge University (1999); Docteur Honoris Causa, University of Paris VI, Pierre et Marie Curie (1999); Elected to the American Academy of Arts and Sciences (1999); ACS Remsen Award, Maryland Section (2000); Foreign Fellow, Royal Society (2002).
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